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St. Louis (December 4, 2002) - Divergence, Inc. was a presenting company at the
first Partnering for Global Health Forum in Washington D.C. today sponsored by the Biotechnology
Industry Organization (BIO) and the Bill and Melinda Gates Foundation. The goal of the forum is to
examine opportunities to apply cutting-edge biotechnology to the health problems of developing
countries.
"The Divergence discovery approach has immediate application to the development of drugs and vaccines
against human parasitic nematodes" said James P. McCarter, M.D., Ph.D., President and Chief Scientific
Officer of Divergence and forum presenter. "We have identified numerous targets that are specific to
nematodes and essential to their lifecycles, and most of these targets are present in important human
parasites. We are pleased to have been selected to share our recent results with an audience interested
in world health."
"Nearly half the world's population is infected with one or more nematode species including hookworm,
Ascaris, whipworm, and the filarial worms that cause elephantiasis," continued McCarter. Parasitic
nematode diseases are the most important human tropical diseases after malaria, and the morbidity they
cause rivals diabetes and lung cancer. No vaccines exist, and more classes of effective drugs are needed.
In parallel with the substantial strides Divergence has made in applying our discoveries to plant and
animal health, we are very interested in opportunities to direct our findings to human parasites. For
instance, one of our lead chemistries that shows promise for the control of plant parasitic nematodes is
also effective in vitro against human filarial nematodes."
Divergence, Inc. is a research and development company dedicated to the discovery of effective and
ecologically sound strategies for the control of parasites and other pests. The company's initial
focus is on parasitic nematodes, one of the world's major pest groups. Nematodes are roundworms that
cause billions of dollars in damage annually to numerous crops, including corn, soybeans, cotton,
strawberries and bananas. Nematodes also cause widespread disease in animals, including infections
such as heartworm in dogs and cats and intestinal worms in livestock. Nematode-induced human diseases
include elephantiasis and African river blindness.
For more information on Divergence, visit www.divergence.com.
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